Serveur d'exploration sur la grippe en Espagne

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Clinical characteristics and outcome of patients with pandemic 2009 Influenza A(H1N1)v virus infection admitted to hospitals with different levels of health-care.

Identifieur interne : 000338 ( Main/Exploration ); précédent : 000337; suivant : 000339

Clinical characteristics and outcome of patients with pandemic 2009 Influenza A(H1N1)v virus infection admitted to hospitals with different levels of health-care.

Auteurs : Manuel Gutiérrez-Cuadra ; José Luis González-Fernández ; Paz Rodríguez-Cundin ; Concepci N Fari As-Álvarez ; María Victoria San Juan ; José Antonio Parra ; Miguel Carrascosa ; María Carmen Fari As

Source :

RBID : pubmed:22488543

Descripteurs français

English descriptors

Abstract

BACKGROUND

The outcome of patients with influenza A 2009 (H1N1)v virus infection taking into account hospital type has not been elucidated.

OBJECTIVES

To compare risk factors, clinical features and outcome of patients admitted to 3 public hospitals with different levels of health-care.

METHODS

Prospective study of all non-pregnant adult patients admitted to 3 hospitals with pandemic H1N1 infection, from June 1 to December 31 and followed up until 1 month after discharge.

RESULTS

During the study period, 111 patients with a mean age of 49 years (15-89) were hospitalized: 52 in hospital 1 (900-bed tertiary-teaching-hospital), 33 in hospital 2 (315-beds secondary-hospital) and 26 in hospital 3 (150-beds primary-care-hospital).Overall 80% of patients had at least 1 comorbid condition with no differences between hospitals. Symptoms or signs on admission were similar except for cough (P=0.01) more frequent in patients in hospital 1 and dyspnea (P=0.05), myalgia, arthralgia (P=0.04) and hypoxemia (P=0.009) present in more patients in hospital 2. In-hospital mortality rates were not statistically different between hospitals. In the stepwise analysis, independent predictors of mortality were pneumonia on admission (adjusted OR=8.68, 95%CI 1.0-82.43) and cardiac complications during hospitalization (adjusted OR=13.2, 95%CI 1.67-103.98).

CONCLUSIONS

Mortality of patients with pandemic H1N1 infection was influenced by patients underlying conditions, severity of disease (pneumonia) on admission and complications during hospitalization. Hospital-characteristics do not appear to have influenced severe outcome.


PubMed: 22488543


Affiliations:


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Le document en format XML

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<term>Data Collection (MeSH)</term>
<term>Disease Outbreaks (MeSH)</term>
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<term>Influenza, Human (drug therapy)</term>
<term>Influenza, Human (epidemiology)</term>
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<term>Middle Aged (MeSH)</term>
<term>Oseltamivir (therapeutic use)</term>
<term>Prospective Studies (MeSH)</term>
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<front>
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<p>
<b>BACKGROUND</b>
</p>
<p>The outcome of patients with influenza A 2009 (H1N1)v virus infection taking into account hospital type has not been elucidated.</p>
</div>
<div type="abstract" xml:lang="en">
<p>
<b>OBJECTIVES</b>
</p>
<p>To compare risk factors, clinical features and outcome of patients admitted to 3 public hospitals with different levels of health-care.</p>
</div>
<div type="abstract" xml:lang="en">
<p>
<b>METHODS</b>
</p>
<p>Prospective study of all non-pregnant adult patients admitted to 3 hospitals with pandemic H1N1 infection, from June 1 to December 31 and followed up until 1 month after discharge.</p>
</div>
<div type="abstract" xml:lang="en">
<p>
<b>RESULTS</b>
</p>
<p>During the study period, 111 patients with a mean age of 49 years (15-89) were hospitalized: 52 in hospital 1 (900-bed tertiary-teaching-hospital), 33 in hospital 2 (315-beds secondary-hospital) and 26 in hospital 3 (150-beds primary-care-hospital).Overall 80% of patients had at least 1 comorbid condition with no differences between hospitals. Symptoms or signs on admission were similar except for cough (P=0.01) more frequent in patients in hospital 1 and dyspnea (P=0.05), myalgia, arthralgia (P=0.04) and hypoxemia (P=0.009) present in more patients in hospital 2. In-hospital mortality rates were not statistically different between hospitals. In the stepwise analysis, independent predictors of mortality were pneumonia on admission (adjusted OR=8.68, 95%CI 1.0-82.43) and cardiac complications during hospitalization (adjusted OR=13.2, 95%CI 1.67-103.98).</p>
</div>
<div type="abstract" xml:lang="en">
<p>
<b>CONCLUSIONS</b>
</p>
<p>Mortality of patients with pandemic H1N1 infection was influenced by patients underlying conditions, severity of disease (pneumonia) on admission and complications during hospitalization. Hospital-characteristics do not appear to have influenced severe outcome.</p>
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<Month>11</Month>
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<AbstractText Label="METHODS" NlmCategory="METHODS">Prospective study of all non-pregnant adult patients admitted to 3 hospitals with pandemic H1N1 infection, from June 1 to December 31 and followed up until 1 month after discharge.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">During the study period, 111 patients with a mean age of 49 years (15-89) were hospitalized: 52 in hospital 1 (900-bed tertiary-teaching-hospital), 33 in hospital 2 (315-beds secondary-hospital) and 26 in hospital 3 (150-beds primary-care-hospital).Overall 80% of patients had at least 1 comorbid condition with no differences between hospitals. Symptoms or signs on admission were similar except for cough (P=0.01) more frequent in patients in hospital 1 and dyspnea (P=0.05), myalgia, arthralgia (P=0.04) and hypoxemia (P=0.009) present in more patients in hospital 2. In-hospital mortality rates were not statistically different between hospitals. In the stepwise analysis, independent predictors of mortality were pneumonia on admission (adjusted OR=8.68, 95%CI 1.0-82.43) and cardiac complications during hospitalization (adjusted OR=13.2, 95%CI 1.67-103.98).</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Mortality of patients with pandemic H1N1 infection was influenced by patients underlying conditions, severity of disease (pneumonia) on admission and complications during hospitalization. Hospital-characteristics do not appear to have influenced severe outcome.</AbstractText>
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<name sortKey="Carrascosa, Miguel" sort="Carrascosa, Miguel" uniqKey="Carrascosa M" first="Miguel" last="Carrascosa">Miguel Carrascosa</name>
<name sortKey="Fari As Lvarez, Concepci N" sort="Fari As Lvarez, Concepci N" uniqKey="Fari As Lvarez C" first="Concepci N" last="Fari As-Álvarez">Concepci N Fari As-Álvarez</name>
<name sortKey="Fari As, Maria Carmen" sort="Fari As, Maria Carmen" uniqKey="Fari As M" first="María Carmen" last="Fari As">María Carmen Fari As</name>
<name sortKey="Gonzalez Fernandez, Jose Luis" sort="Gonzalez Fernandez, Jose Luis" uniqKey="Gonzalez Fernandez J" first="José Luis" last="González-Fernández">José Luis González-Fernández</name>
<name sortKey="Gutierrez Cuadra, Manuel" sort="Gutierrez Cuadra, Manuel" uniqKey="Gutierrez Cuadra M" first="Manuel" last="Gutiérrez-Cuadra">Manuel Gutiérrez-Cuadra</name>
<name sortKey="Parra, Jose Antonio" sort="Parra, Jose Antonio" uniqKey="Parra J" first="José Antonio" last="Parra">José Antonio Parra</name>
<name sortKey="Rodriguez Cundin, Paz" sort="Rodriguez Cundin, Paz" uniqKey="Rodriguez Cundin P" first="Paz" last="Rodríguez-Cundin">Paz Rodríguez-Cundin</name>
<name sortKey="San Juan, Maria Victoria" sort="San Juan, Maria Victoria" uniqKey="San Juan M" first="María Victoria" last="San Juan">María Victoria San Juan</name>
</noCountry>
</tree>
</affiliations>
</record>

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HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000338 | SxmlIndent | more

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Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    GrippeEspagneV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:22488543
   |texte=   Clinical characteristics and outcome of patients with pandemic 2009 Influenza A(H1N1)v virus infection admitted to hospitals with different levels of health-care.
}}

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       | NlmPubMed2Wicri -a GrippeEspagneV1 

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Data generation: Fri Sep 25 11:01:38 2020. Site generation: Sat Feb 13 17:38:04 2021